Progesterone: inhibits mast cell secretion. (Plus estrogen info)

1y ago by MyPatientMatch User

Progesterone inhibits mast cell secretion.
Vasiadi M, et al. [With Theoharides]
Int J Immunopathol Pharmacol.
2006 Oct-Dec.

"These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy."
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These quotes were found in this:
Premenstrual asthma: from pathopysiology to treatment strategies.

Sex hormones regulate MC functionality and distribution in several tissues [42][43][44][45][46][47], both in physiological and pathological conditions. In this regard, a relationship between female sex hormones, MC and development of asthma and allergy has been suggested [46][47][48][49]. Furthermore, the presence of sex steroid receptors on MC indicates that sex hormones may exert their biological effects by binding to these receptors [49].

Found in this:
Premenstrual asthma: from pathopysiology to treatment strategies.
[Asthma is a mast cell issue]
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Estrogens, including environmental estrogenic pollutants, can induce mast cell degranulation in vitro (109, 110), whereas progesterone appears to inhibit histamine secretion (111).
A greater understanding of the relationships between hormone levels, stress, and mast cell activation will likely open doors to therapeutic measures in human autoimmunity.
Vliagoftis, H., V. Dimitriadou, W. Boucher, J. J. Rozniecki, I. Correia, S. Raam, T. C. Theoharides. 1992. Estradiol augments while tamoxifen inhibits rat mast cell secretion. Int. Arch. Allergy Immunol. 98: 398-409.

Narita, S., R. M. Goldblum, C. S. Watson, E. G. Brooks, D. M. Estes, E. M. Curran, T. Midoro-Horiuti.2007. Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environ. Health Perspect. 115: 48-52.

Vasiadi, M., D. Kempuraj, W. Boucher, D. Kalogeromitros, T. C. Theoharides. 2006. Progesterone inhibits mast cell secretion. Int. J. Immunopathol.
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The presence of MCs in the uterus has been already described in many species including human [15], mouse [16], rat [17], hamster [18] as well as goat [19]. Besides, the number of MCs in the uterus was shown to fluctuate during estrous cycle suggesting an influence of female sex hormones on MC recruitment to the uterus [17].

Thereby, these hormones might act directly as MCs express estradiol and progesterone receptors (ER and PR) [20-26].

Zaitsu et al. demonstrated that estradiol rapidly stimulated MC degranulation which could be blocked by tamoxifen, a tissue specific ER antagonist, clearly indicating that estradiol-induced MC degranulation throughout one of its receptors.

Bone marrow-derived MCs (BMMCs) isolated from ER knockout animals did not degranulate in response to E2 treatment confirming that the E2 effect on MCs is more likely mediated by the ER [25].

Ovariectomized mice, in which estradiol and progesterone are almost absent, have less number of uterine MCs compared to control, non-ovariectomized animals [20]. Hormonal replacement, estradiol alone or in combination with progesterone, restored the number of uterine MCs after ovariectomization, which was comparable to the levels observed in control mice [20].

Hormonal replacement additionally induced an augmentation in the levels of MC-related proteases expression in the uterus as well as boosted MC degranulation [20].

Explains the usefulness to me (in younger years) of progesterone troches (compounded soft lozenge/ as needed) for PMS SX of higher fibro pain, H/A, mood. (Some masties don't tolerate progesterone. I wonder if maybe the form is important to some people...but it tends to be a cautious group that reads a lot. Did folks try Bioidentical? Topical rather than oral might help? Sublingual like my troches?)
[I have a part 2 which did not show up yet in the cartoon reply symbol here.]

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